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. 2015 Jun 18;6(26):22496–22512. doi: 10.18632/oncotarget.4318

Table 3. Trop-2 expression and SN-38 sensitivity in breast cancer cell lines.

Cell Line Receptor status Trop-2 surface expressiona IC50 (nM)
SN-38
SK-BR-3 HER2+ 328,281 ± 47, 996 2
MDA-MB-468 TNBC 301,603 ± 29, 470 2
HCC38 TNBC 181,488 ± 69, 351 2
MCF-7 ER+ 110,646 ± 17, 233 33
HCC1806 TNBC 91,403 ± 20, 817 1
MDA-MB-231 TNBC 32,380 ± 5, 460 6
a

Mean ± SD number of surface Trop-2 molecules per cell from three separate assays.