Table 3. Trop-2 expression and SN-38 sensitivity in breast cancer cell lines.
Cell Line | Receptor status | Trop-2 surface expressiona | IC50 (nM) SN-38 |
---|---|---|---|
SK-BR-3 | HER2+ | 328,281 ± 47, 996 | 2 |
MDA-MB-468 | TNBC | 301,603 ± 29, 470 | 2 |
HCC38 | TNBC | 181,488 ± 69, 351 | 2 |
MCF-7 | ER+ | 110,646 ± 17, 233 | 33 |
HCC1806 | TNBC | 91,403 ± 20, 817 | 1 |
MDA-MB-231 | TNBC | 32,380 ± 5, 460 | 6 |
Mean ± SD number of surface Trop-2 molecules per cell from three separate assays.