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. 2015 Jun 10;6(26):22666–22679. doi: 10.18632/oncotarget.4433

Figure 3. Survival curve and combination index (CI) of the sequential and simultaneous combination therapy in the p53 wild type cell line A549.

Figure 3

A. 1. Survival curve after 24 hours of CDDP (0-20 μM) monotherapy and in simultaneous combination with 5 μM, 10 μM, or 25 μM Nutlin-3. 2. The corresponding combination index for each Nutlin-3 concentration is shown in detail on the right. Each data point represents the corresponding CDDP concentration (0.5-1-2-5-10-20 μM). B. 1. Survival curve after 24 hours of CDDP (0-20 μM) monotherapy and sequential combination therapy with 5 μM, 10 μM, or 25 μM Nutlin-3. 2. The corresponding combination index for each Nutlin-3 concentration is shown in detail on the right. Each data point represents the corresponding CDDP concentration (0.5-1-2-5-10-20 μM). The supporting data for this figure (Mean IC50-values and mean CI) can be found in Table 1.