Table 2. Relationship between DICER1 protein expression and baseline clinical or pathological characteristics of 79 adult patients with ACC (only tumor samples derived from primary surgery).

	Weak DICER1 expression	Strong DICER1 expression	p
n (%)	40 (51%)	39 (49%)
Score, median	2.4 (0–3.5)	5.4 (3.6–7.0)
Age, median (yr)	35 (15–67)	45 (18–81)	0.02
Sex [male, n (%)]	11 (28)	6 (15)	0.19
Tumor size, median (cm)	12.3 (6–23)	9.0 (0–23)	0.001
Staging (ENSAT) [n (%)]			0.04
1–2	18 (45)	25 (68)
3–4	22 (55)	12 (32)
Hormonal status [n (%)]			0.76
Cushing	6 (16)	7 (19)
Non-Cushing	31 (84)	30 (81)
Weiss score, median	6 (3–9)	4 (3–9)	0.02
Ki67 index (%)			0.47
<10	25 (63)	26 (70)
≥10	15 (37)	11 (30)
Metastasis or local recurrence [n (%)]*
Affected patients	29 (72)	15 (38)	0.002
Non-affected patients	11 (28)	24 (62)

ACC, adrenocortical carcinoma