Figure 4. The oncogenic roles of FBXO22 rely on its regulation of KLF4.

A–B. Cell proliferation (A) and invasion (B) assays in cells with FBXO22 overexpression and (or) KLF4 knockdown as indicated. HepG2 cells were transfected with adenovirus expressing GFP or FBXO22 for 24 hr, and then transfected with adenoviral shRNA targeting KLF4 or a negative control (NC) for another 24 hr. C. Relative mRNA levels of p21 and Cyclin B1 in HepG2 cells as in (A-B)