Figure 5.

FBXO22 promote HCC growth in vivo

A–B. HepG2 cells stably transfected with FBXO22 or GFP were injected into nude mice and followed up for tumorigenesis. Growth curve of tumor volumes (A) and tumor weights (B) were taken 4 weeks after injection. (n = 6–8 for each group) C. Representative protein levels of FBXO22, GFP and KLF4 were determined in the two groups of tumors. D–E. mRNA and protein levels of p21 and Cyclin B1 in two groups of tumors were determined by real-time PCR and Western blot.