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. 2015 Feb 13;6(26):22857–22868. doi: 10.18632/oncotarget.3127

Figure 1. Surgical resection enhances primary tumor regrowth.

Figure 1

(A) IHC labeling of eye sections from non-tumor-bearing (ret−/−) and tumor-bearing (Ret+/−) mice, with S100B (red) and Ki67 (blue). At the time of surgery (3wk after birth) Ret+/− eyes show signs of hyperplasia (arrow). 4 weeks after surgery (VE), tumor regrowth has occurred and tumors were comparable to those in orbits of control mice. (B) Quantification of the number of tumor nodules relapsing within the orbit of the eye 4 and 6wk after surgery. Each point represent one mouse; 1-way ANOVA, N.S. not significant (n = 12–14 mice). (C) The percentage of Ki67+ cells in the relapsed tumors 4 and 6wks after surgery. Each point represents one tumor nodule; 1-way ANOVA, *P < 0.05 (n = 4–6 mice). (D) Quantification of the area of the relapsed tumor nodules 4 and 6wk after surgery. Each point represents one tumor nodule; 1-way ANOVA, **P < 0.01 (n = 3–5 mice).