Table 1. Correlation of Cbl-b expression with clinic-pathological parameters in 154 RANK positive breast cancer patients.
| Clinic-pathological parameters | n | Cbl-b expression† (%) | p |
|---|---|---|---|
| Histological type | 0.650 | ||
| invasive ductal carcinomas | 137 | 96(70.1) | |
| invasive lobular carcinoma and others | 17 | 11(64.7) | |
| Age (years) | 0.495(exact) | ||
| ≤35 | 10 | 6(60.0) | |
| >35 | 144 | 101(70.1) | |
| Tumor size(cm) | 0.137 | ||
| ≤2 | 49 | 38(77.6) | |
| >2 | 105 | 60(65.7) | |
| PN stage | 0.063 | ||
| 0 | 63 | 49(77.8) | |
| 1-3 | 91 | 58(63.7) | |
| Histology grade | 0.064(exact) | ||
| I | 14 | 13(92.9) | |
| II+III | 123 | 82(66.7) | |
| ER/PR status†† | 0.457 | ||
| Negative | 74 | 49(66.2) | |
| Positive | 78 | 56(71.8) | |
| Unknown | 2 | ||
| HER2 status§ | 0.985 | ||
| Negative | 88 | 62(70.5) | |
| Positive | 64 | 45(70.3) | |
| Unknown | 2 | ||
| Triple negative | 0.281 | ||
| no | 116 | 83(71.6) | |
| yes | 31 | 23(62.2) | |
| Unknown | 1 | ||
| Metastasis | 0.004 | ||
| no | 107 | 82(76.6) | |
| yes | 47 | 25(53.2) |
P values shown in bold are statistically significant (two-sided, p < 0.05)
†
Cbl-b expression was classified as “negative”: arbitrary scale=0-1, and “positive”: arbitrary scale= 2-6, as described in materials and methods.
††
ER/PR status: Estrogen receptor or progesterone receptor status by immunohistochemistry (IHC); negative: ER and PR double negative; positive: ER or PR positive.
§
HER2 status: HER2 positive status is IHC 3+ or fluorescence in situ hybridization (FISH) positive; HER2 negative status is IHC 0, 1+ or FISH negative, if. IHC 2+, FISH is applied to confirm the HER2 status.