Table 2. Cox univariate and multivariate analysis of disease-free survival (A) and disease-specific survival (B) in RANK positive breast cancer patients (n = 154).

Risk factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	p	HR(95% CI)	p
A Disease-free survival
Cbl-b positive versus negative	0.445 (0.250-0.791)	0.006	0.539(0.301-0.966)	0.038
Age ≤35 years versus >35 years	2.911 (1.232-6.882)	0.015	2.381 (1.004-5.649)	0.049
Tumor size >2 cm versus <2cm	2.919 (1.307-6.518)	0.009	2.198 (0.967-4.999)	0.060
Lymph node metastasis positive versus negative	2.682 (1.364-5.272)	0.004	1.988 (0.992-3.984)	0.053
Histology grade2-3 versus1	2.894 (0.699-11.975)	0.143
ER/PR positive versus negative	0.920 (0.519-1.631)	0.776
HER2 positive versus negative	1.357 (0.765-2.408)	0.297
B Breast cancer-specific survival
Cbl-b positive versus negative	0.492 (0.249-0.969)	0.040	0.631 (0.317-1.256)	0.190
Age ≤35 years versus >35 years	4.647 (1.899-11.376)	0.001	4.035 (1.643-9.908)	0.002
Tumor size >2 cm versus <2cm	3.839 (1.352-10.905)	0.012	2.997 (1.039-8.642)	0.042
Lymph node metastasis positive versus negative	2.998 (1.305-6.888)	0.010	2.125 (0.909-4.967)	0.082
Histology grade 2-3 versus1	2.123 (0.506-8.904)	0.304
ER/PR positive versus negative	0.994 (0.534-2.044)	0.905
HER2 positive versus negative	1.550 (0.791-3.036)	0.202

HR, hazard ratio; CI, confidence interval.

p values shown in bold are statistically significant (Two-sided, p < 0.05).