Figure 3. Extracellular in vivo levels of miRNAs in breast cancers and normal breast tissue of women during various hormone exposures.

Microdialysis was used for sampling of extracellular miRNAs in vivo in breast cancer and normal adjacent breast tissue in women before surgery, n = 13, in normal human breast tissue in pre-menopausal women, n = 16, and postmenopausal women, n = 12, in normal human breast tissue and abdominal subcutaneous fat of pre-menopausal women during the follicular and luteal phases of one menstrual cycle, n = 8, and in normal human breast tissue and abdominal subcutaneous fat of postmenopausal women before and after six weeks of tamoxifen therapy, n = 12. Bars represent mean±SEM, *p < 0.05, **p < 0.01.