Table 2. microRNAs in response to exercise training.
| MicroRNAs | Targets | Function | References |
|---|---|---|---|
| miR-1, miR-133a, miR-133b (down) | RhoA, Cdc42, NELFA | 1. Increase cell differentiation & growth | 88–90 |
| miR-214 (down) | SERCA2a | 1. Increase left ventricular myocyte mass 2. Increase cell contraction |
91 |
| miR-29a, miR-29c(up) | COL1A1, COL3A | 1. Increase ventricular compliance 2. Decrease cardiac collagen |
92, 93 |
| miR-222 (up) | P27, HMBOX1, HIPK1/2 | Increase cardiac growth | 94, 95 |
| miR-126 (up) | MAPK PI3K/Akt/eNOS | Increase cardiac angiogenesis | 97 |