Figure 5. SNS-032 suppresses tumorigenecity of ovarian cancer cells with CCNE1 overexpression.

A., B. Kaplan-Meier curve summarizing survival of mice injected with OCC1 A. and OVCAR429 cells B.. Female athymic nude mice were injected i.p. with OCC1 or OVCAR429 cells (1 × 10⁷ cells/mouse) for 5 days followed by administration of 30 mg/kg SNS-032twice per week until animal died. C. OCC1 cells (1 × 10⁷ cells/mouse) were injected i.p. to nude mice for 5 days followed by SNS-032 treatment for 3 weeks. Mice were sacrificed and metastatic implants were collected/weighed. Data are means ± SE. n = 10. *, P < 0.001 vs vehicle.