Figure 4. Kaplan-Meier survival analysis by genetic signature and co-evaluating genetic signature with clinical variables.

The genetic signature showed prognostic relevance across the whole cohort a. The genetic signature was associated with overall survival in grade II gliomas b. and grade III gliomas c. Prognostic association of the genetic signature was demonstrated in patients at or younger than 50 years d. as well as patients above 50 years e. The genetic signature exhibited prognostic relevance in astrocytic gliomas g. and trend in oligodendroglial / oligoastrocytic gliomas f. OS, overall survival; mut, mutant; wt, wild-type.