Table 2. Univariate analysis of clinical and molecular variables.
| n | HR | [95% CI] | Median OS (years) | p | |
|---|---|---|---|---|---|
| Histological grade | |||||
| Grade II | 142 | 1 | 10.2 | <0.0001 | |
| Grade III | 72 | 4.045 | [2.629–6.223] | 2.3 | |
| Age | |||||
| ≤50 years | 172 | 1 | 10 | <0.0001 | |
| >50 years | 42 | 2.43 | [1.549–3.812] | 2.3 | |
| Histological type | |||||
| Astrocytic | 149 | 2.266 | [1.445–3.555] | 5.5 | 0.0003 |
| Oligodendroglial / Oligoastrocytic | 65 | 1 | 11 | ||
| IDH1/2 | |||||
| Mutant | 156 | 0.431 | [0.286–0.649] | 10.1 | <0.0001 |
| Wild-type | 58 | 1 | 2.2 | ||
| 1p/19q codeletion | |||||
| Codeleted | 38 | 0.274 | [0.142–0.529] | 11.8 | <0.0001 |
| Non-codeleted | 176 | 1 | 5.6 | ||
| TERTp | |||||
| Mutant | 61 | 0.73 | [0.472–1.128] | 10.5 | 0.155 |
| Wild-type | 153 | 1 | 6.5 | ||
| EGFR | |||||
| Amplified | 9 | 9.082 | [4.373–18.863] | 1.1 | <0.0001 |
| Non-amplified | 205 | 1 | 9.9 | ||
| Genetic signature | |||||
| IDHmut-OT | 57 | 1 | 11.8 | <0.0001 | |
| IDHmut | 99 | 2.863 | [1.643–4.989] | 5.9 | |
| IDHwt | 42 | 2.883 | [1.498–5.547] | 5 | |
| IDHwt-ET | 16 | 17.65 | [8.603–36.208] | 0.6 |
n, number of case; HR, hazard ratio; 95% CI, 95% confidence interval; OS, overall survival; IDHmut-OT, IDH1/2 mutated and either 1p/19q codeleted or TERTp mutated; IDHmut, IDH1/2 mutated only; IDHwt, IDH1/2 wild-type, TERTp wild-type and EGFR non-amplified; IDHwt-ET, IDH1/2 wild-type and either TERTp mutated or EGFR amplified.