Table 4. Univariate and multivariate analysis of the factors associated with DRFS.
| Training set | Univariate analysis | HR | Multivariate analysis | P value |
|---|---|---|---|---|
| Factors | P value | 95% CI | ||
| RAD54B (High vs Low group) | 0.0013 | 4.31 | 1.53 to 13.1 | 0.0060 |
| T stage (T1-2 vs T3-4) | 0.14 | 2.96 | 0.57 to 54.4 | 0.23 |
| N stage (N0 vs N1-2) | 0.14 | 2.44 | 0.88 to 7.23 | 0.088 |
| Cell differentiation (WD vs MD/PD) | 0.073 | - | - | - |
| Lymphatic invasion (positive vs negative) | 0.090 | - | - | - |
| Venous invasion (positive vs negative) | 0.33 | - | - | - |
| Preoperative CEA (<5.0 vs ≥5.0) | 0.51 | - | - | - |
| Preoperative CA19-9 (<37 vs ≥37) | 0.89 | - | - | - |
| Age (<65 vs ≥65) | 0.37 | - | - | - |
| Location (Colon vs Rectum) | 0.94 | - | - | - |
| Sex (Male vs Female) | 0.34 | - | - | - |
| Tumor size (mm) (<50 vs ≥50) | 0.49 | - | - | - |
| Validation set | Univariate analysis | HR | Multivariate analysis | P value |
|---|---|---|---|---|
| Factors | P value | 95% CI | ||
| RAD54B (High vs Low group) | 0.024 | 3.627 | 1.23 to 10.7 | 0.021 |
| T stage (T1-2 vs T3-4) | 0.18 | 3.432 | 0.66 to 63.1 | 0.17 |
| N stage (N0 vs N1-2) | 0.13 | 2.182 | 0.74 to 7.21 | 0.16 |
| Cell differentiation (WD vs MD/PD) | 0.34 | - | - | - |
| Lymphatic invasion (positive vs negative) | 0.54 | - | - | - |
| Venous invasion (positive vs negative) | 0.094 | - | - | - |
| Preoperative CEA (<5.0 vs ≥5.0) | 0.073 | - | - | - |
| Preoperative CA19-9 (<37 vs ≥37) | 0.19 | - | - | - |
| Age (<65 vs ≥65) | 0.41 | - | - | - |
| Location (Colon vs Rectum) | 0.74 | - | - | - |
| Sex (Male vs Female) | 0.71 | - | - | - |
| Tumor size (mm) (<50 vs ≥50) | 0.84 | - | - | - |
WD = well differentiated; MD = moderately differentiated; PD = poorly differentiated; HR = hazard ratio; CI = confidence interval.