Table 1. Basal mRNA and protein relative levels of antiapoptotic factors in MCL cells.
| MCL cell lines | Acadesine sensitivity % Cytotoxicity 2 mM | a Protein levels | b mRNA levels | ||
|---|---|---|---|---|---|
| Bcl-2 | Bcl-XL | BCL2 | BCLXL | ||
| GRANTA-519 | 21.61 | 1.53 | 1.02 | 13.68 | 1.80 |
| HBL-2 | 19.81 | 1.66 | 0.54 | 17.23 | 1.19 |
| JEKO-1 | 60.43 | 0.76 | 0.98 | 5.94 | 1.29 |
| JVM-2 | 37.80 | 1.00 | 1.00 | 1.00 | 1.00 |
| MAVER | 48.19 | 1.48 | 1.75 | 10.99 | 2.54 |
| MINO | 17.71 | 1.14 | 1.85 | 5.96 | 0.87 |
| REC-1 | 84.29 | 0.90 | 2.04 | 3.89 | 1.01 |
| UPN-1 | 65.45 | 0.00 | 1.40 | 0.00 | 1.05 |
| Z-138 | 23.67 | 1.31 | 1.93 | 4.58 | 2.67 |
a
Protein expression was quantified by densitometry
b
mRNA levels were quantified by qRT-PCR