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. 2015 May 22;6(25):21283–21300. doi: 10.18632/oncotarget.4238

Figure 5. FUCA inhibition in MDA-MB-231 cells produces a selective pro-metastatic pressure on primary tumor cells.

Figure 5

A. Five stable FUCA1-knock-down MDA-MB-231 clones (FUCA1 Si-1 to Si-5) were selected. B. Cell proliferation assays were performed using wild type MDA-MB-231 cells (control) or those stably expressing FUCA1 Si-2, Si-2, or scramble (Sc) (*P = 0.001). C. Wound healing migration and invasion assays were performed using control MDA-MB-231 cells or those stably expressing FUCA1-Si or FUCA1-Sc for 24 h (*P < 0.001). D. FUCA1 expression was stably knocked down in MDA-MB-231 cells. FAK/Src protein levels in these cells were examined by immunoblotting analysis. The expression of α-tubulin was used as a control for equal protein loading.