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. 2015 May 19;6(25):21341–21352. doi: 10.18632/oncotarget.4179

Figure 4. The effect on the EGFR downstream signaling pathways in response to ZD6474.

Figure 4

A. EGFR expression in osteosarcoma cells. B. ZD6474 inhibits the phosphorylation of Akt and ERK in osteosarcoma cells. Cells were treated with 10 μM ZD6474 for 2 hours, and protein levels were checked by Western blotting analysis as described in Materials and Methods.