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. 2015 May 24;6(25):21379–21394. doi: 10.18632/oncotarget.4091

Figure 4. Pharmacokinetics and biodistribution of GS25 and GS25NP.

Figure 4

The plasma concentration-time curves following A. intravenous administration of 20 mg/kg GS25 or B. oral administration of GS25 (100 mg/kg) or GS25NP (20 and 100 mg/kg) to CD-1 mice. C. The plasma concentration-time curves following oral administration of GS25 (100 mg/kg) or GS25NP (100 mg/kg) to nude mice bearing PC3 xenograft tumors. D. The time-dependent distribution of GS25 and GS25NP in PC3 xenograft tumors. E. The pharmacokinetic parameters of GS25 and GS25NP in CD-1 mice and nude mice bearing PC3 tumors. The concentration unit for GS25NP is GS25 equivalent in all experiments.