Table 3. Univariate and multivariate Cox regression analysis on microRNA expression levels with cancer-specific survival in validation cohort (n = 159).

	Univariate		Multivariate
Prognostic factor	HR (95% CI)	P value	HR (95% CI)	P value
Age (≧65 versus < 65)	1.29 (0.61–2.80)	0.4991
Gender (Female versus Male)	1.38 (0.63–2.92)	0.4069
TNM Stage (II, III versus I) (IV versus I)	12.2 (3.04–81.0) 194 (50.4–1295)	0.0002 < 0.0001	12.3 (3.01–82.3) 223 (49.3–1787)	0.0003 < 0.0001
Grade (G3, 4 versus G1, 2)	6.12 (2.68–13.2)	< 0.0001	2.16 (0.91–4.92)	0.0794
Vein invasion (yes versus no)	2.71 (0.95–6.78)	0.0593
miR-21-3p (high versus low)	2.75 (1.25–6.65)	0.0108	0.58 (0.21–1.66)	0.3042
miR-193a-3p (high versus low)	0.91 (0.42–1.93)	0.8040
miR-34a-5p (high versus low)	1.36 (0.42–2.94)	0.4162
miR-193b-5p (high versus low)	1.87 (0.87–4.22)	0.1053
miR-27a-3p (high versus low)	1.21 (0.57–2.60)	0.6215