Table 4. Univariate and multivariate Cox regression analysis on microRNA expression levels with progression-free survival in validation cohort (n = 140).

	Univariable		Multivaliate
Prognostic factor	HR (95% CI)	P value	HR (95% CI)	P value
Age (≧65 versus < 65)	0.76 (0.35–1.62)	0.4791
Gender (Female versus Male)	0.88 (0.36–1.94)	0.7560
TNM Stage (II, III versus I)	7.76 (3.54–18.3)	< 0.0001	8.39 (3.81–19.9)	< 0.0001
Grade (G3, 4 versus G1, 2)	1.73 (0.41–4.98)	0.4050
Vein invasion (yes versus no)	1.86 (0.53–5.00)	0.2932
miR-21-3p (high versus low)	1.38 (0.65–3.01)	0.4061
miR-193a-3p (high versus low)	1.93 (0.90–4.37)	0.0942
miR-34a-5p (high versus low)	0.97 (0.45–2.08)	0.9382
miR-193b-5p (high versus low)	1.30 (0.61–2.83)	0.4976
miR-27a-3p (high versus low)	2.33 (1.07–5.47)	0.0330	2.71 (1.23–6.42)	0.0131