(a).

Gene/rs number	Genotype	Controls number	T1					T2
			Patients	Odds ratio	0.95 confidence intervals		p	Patients	Odds ratio	0.95 confidence intervals		p
			number		Lower limit	Upper limit		number		Lower limit	Upper limit
DROSHA
6877842	CC	15	1	Ref.				0	Ref.
	CG	79	5	0.9494	0.1034	8.7141	0.6590F	6	NA
	GG	76	4	0.7595	0.0793	7.2769	0.5940F	11	NA
DICER1
3742330	AA	63	1	Ref.				3	Ref.
	AG	103	8	4.8932	0.5978	40.0546	0.0967F	12	2.4466	0.6645	9.0082	0.1669
	GG	4	0	NA				0	NA
13078	AA	10	0	Ref.				1	Ref.
	AT	124	8	NA				8	0.6452	0.0732	5.6871	0.5239F
	TT	36	2	NA				8	2.2222	0.2478	19.9312	0.4181F
DGCR8
1640299	GG	16	0	Ref.				1	Ref.
	GT	93	2	NA				9	1.5652	0.1854	13.2126	0.5614F
	TT	61	4	NA				5	1.3115	0.1429	12.0333	0.6432F
3757	AA	15	1	Ref.				0	Ref.
	AG	119	7	0.8824	0.1014	7.6744	0.6255F	15	NA
	GG	36	1	0.4167	0.0244	7.107	0.5166F	2	NA
417309	AA	8	4	Ref.				2	Ref.
	AG	46	2	0.087	0.0136	0.5564	0.0119F	8	0.6957	0.1243	3.892	0.4909F
	GG	116	3	0.0517	0.0098	0.2719	0.0012F	5	0.1724	0.0288	1.0322	0.0898F
RAN
14035	CC	67	7	Ref.				9	Ref.
	CT	93	2	0.2058	0.0415	1.0221	0.0383F	6	0.4803	0.1632	1.4139	0.1761
	TT	10	1	0.9571	0.1063	8.6223	0.7245F	0	NA
TARBP2
784567	AA	35	1	Ref.				1	Ref.
	AG	114	6	1.8421	0.2144	15.8246	0.4907F	8	2.4561	0.2969	20.3221	0.3494F
	GG	21	2	3.3333	0.2846	39.0437	0.3346F	8	13.3333	1.556	114.2517	0.0051F
XPO5
11077	GG	82	2	Ref.				3	Ref.
	GT	44	4	3.7273	0.6565	21.1609	0.1274F	8	4.9697	1.2546	19.686	0.0167F
	TT	34	3	3.6176	0.5784	22.6277	0.1663F	5	4.0196	0.9094	17.7671	0.0634F

^F p values calculated with Fisher's exact probability test.