(b).

Gene/rs number	Genotype	Controls number	Stage III					Stage IV
			Patients	Odds ratio	0.95 confidence intervals		p	Patients	Odds ratio	0.95 confidence intervals		p
			number		Lower limit	Upper limit		number		Lower limit	Upper limit
DROSHA
6877842	CC	15	4	Ref.				1	Ref.
	CG	79	16	0.7595	0.2227	2.5903	0.4371F	24	4.557	0.572	36.3009	0.1034F
	GG	76	31	1.5296	0.4703	4.9749	0.4795	33	6.5132	0.8259	51.3637	0.0341F
DICER1
3742330	AA	63	10	Ref.				10	Ref.
	AG	103	38	2.3243	1.0828	4.9893	0.0276	49	2.9971	1.4173	6.3378	0.0031
	GG	4	0	NA				0	NA
13078	AA	10	1	Ref.				4	Ref.
	AT	124	14	1.129	0.1344	9.4878	0.6945F	17	0.3427	0.0967	1.215	0.1004F
	TT	36	33	9.1667	1.1122	75.5513	0.01450F	38	2.6389	0.7591	9.1733	0.1006F
DGCR8
1640299	GG	16	2	Ref.				4	Ref.
	GT	93	21	1.8065	0.3856	8.4634	0.3533F	18	0.0968	0.0165	0.5686	0.0112F
	TT	61	26	3.4098	0.731	15.9056	0.0836F	26	0.5	0.0841	2.9719	0.3691F
3757	AA	15	2	Ref.				0	Ref.
	AG	119	33	2.0798	0.4526	9.5571	0.2709F	42	NA
	GG	36	10	2.0833	0.4068	10.6686	0.3073F	11	NA
417309	AA	8	4	Ref.				3	Ref.
	AG	46	13	0.5652	0.1467	2.178	0.3094F	13	0.7536	0.1745	3.2541	0.4838F
	GG	116	25	0.431	0.1204	1.5436	0.1704F	35	0.8046	0.2025	3.1973	0.4996F
RAN
14035	CC	67	32	Ref.				29	Ref.
	CT	93	11	0.2476	0.1166	0.5262	0.0001	14	0.3478	0.1708	0.7081	0.0028
	TT	10	3	0.6281	0.1617	2.4405	0.3715F	1	0.231	0.0283	1.8892	0.1277F
TARBP2
784567	AA	35	5	Ref.				1	Ref.
	AG	114	28	1.7193	0.6174	4.788	0.2942	32	9.8246	1.2953	74.5144	0.0075
	GG	21	18	6	1.9403	18.5537	0.0009	26	43.3333	5.4718	343.1724	<0.0001
XPO5
11077	GG	82	9	Ref.				13	Ref.
	GT	44	24	4.9697	2.1259	11.6175	<0.0001	29	4.1573	1.9643	8.799	0.0001
	TT	34	16	4.2876	1.7271	10.644	0.001	14	2.5973	1.1054	6.1026	0.0254

^F p values calculated with Fisher's exact probability test.