Figure 5.

Proposed schematic showing targets of SA transcriptional regulation of insulin signaling pathway. SA prevents insulin resistance in HFD-fed rats by influencing the transcriptional regulation of multiple genes. Gck: glucokinase; Iκbkβ: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; IRS: insulin receptor substrate; KCNJ11: potassium inwardly rectifying channel, subfamily J, member 11; Mapk: mitogen-activated protein kinase; mTOR: mammalian target of rapamycin; Pi3k: phosphoinositide-3-kinase; Pk: pyruvate kinase; and Prkcz: protein kinase C, zeta.