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. Author manuscript; available in PMC: 2016 Oct 7.
Published in final edited form as: Mol Pharm. 2015 Nov 4;12(12):4237–4246. doi: 10.1021/acs.molpharmaceut.5b00430

Figure 2.

Figure 2

(A) Synthesis route of LS662. (B) Chemical structure of cypate. (C) Absorption and emission spectra of pH titrated LS662 in water from pH 2–10. Absorption in basic solution primarily occurs in the visible range, while absorption in acid solution occurs in the NIR. In acidic solution, excitation at 720 nm results in fluorescence at 758 nm. LS662 has a pKa of 5.2. (D) Pseudocolor images of a solution of LS662 at pH 6.0, 6.5, 7.0 and 7.5 (see methods section for solution preparation).