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. 2015 Dec 9;5:17847. doi: 10.1038/srep17847

Figure 2. Developmental changes in the cross-frequency coupling (CFC) and spike-field coherence (SFC) of spontaneous activity.

Figure 2

(A) The normalized LFP amplitudes at beta (15–35 Hz, left) and gamma (40–70 Hz, right) bands corresponding to the phase of theta (3–8 Hz) cycles in the pre-CP (n = 135 recordings in 19 mice), CP (n = 150 in 17 mice) and adult (n = 70 in 15 mice) mice. The data in the active and non-active states are pooled (states pooled). (B) Summarized results of the phase-amplitude CFC modulation index in mice at different stages. (C) The average SFC in the frequency range of 1–90 Hz for all recorded single units from mice at three stages (pre-CP, n = 77 units in 19 mice; CP, n = 106 in 16 mice; adult, n = 35 in 15 mice; states pooled). (D) Quantification of SFC of (C) in three frequency bands (1–10 Hz, 15–35 Hz, 40–70 Hz). Shadow areas in (A,C) represent the site-to-site and the unit-to-unit s.e.m., respectively. Error bars in (B,D) represent s.e.m. The p values were calculated by the unpaired Kolmogorov–Smirnov test.