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. 2015 Nov 20;6:8888. doi: 10.1038/ncomms9888

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(a–c) On culture day 6, hippocampal neurons were infected with Ad.GFP, Ad.TRF2-S or Ad.TRF2-S▵45. The mEPSCs were measured on culture day 15. Representative mEPSC traces from transduced neurons are shown in a and quantification of the frequency and amplitude of mEPSCs is shown in b,c. The frequency of mEPSCs in neurons expressing TRF2-S was significantly greater than those expressing βGal or the TRF2-S▵45 mutant (*P<0.01). (d–i) mEPSCs were measured in hippocampal neurons on culture day 15, which was 7 days after lentiviral transduction with a non-target (NT, scramble) shRNA and target-specific shRNAs for silencing of TRF2-S/sh#1(865) or FMRP/sh#1 (2624). Representative mEPSC traces are shown in d,g. Quantification of the frequency and amplitude of mEPSCs is shown in (e,f,h,i) (*P<0.05). n=15 neurons per condition.