Table 1.

List of requirements for age-appropriate oral drug delivery systems.

Benefit/risk	Criterion for drug product	Product requirements
Efficacy/acceptability	Dosage	Dose flexibility Acceptability of size/volume
	Preparation/administration	Easy and convenient handling Easily administered (correct use)
	Compliance	Minimal impact on lifestyle Acceptable appearance and taste Minimal administration frequency
Patient safety	Bioavailability	Adequate bioavailability
	Excipients	Minimal number of excipients Tolerability
	Stability	Stable during shell life Stable in-use
	Medication error	Minimal risk of dosing error
Patient access	Manufacturability	Robust manufacturing process Commercial viability
	Affordability	Acceptable cost to patient and payers Easily transported and stored Low environmental impact

Data taken from [9].