Table II.

Gene expression data for GUCA2A/Guca2a, GUCA2B/Guca2b and GUCY2C/Gucy2c in IBD and TNBS colitis.

FC with p-Values
Human	UC vs. Healthy		CD vs. Healthy
	FC	p	FC	p
GUCA2A	−4.91	3.28 × 10−13	−2.86	0.0037
GUCA2B	−6.06	1.01 × 10−16	−4.64	7.12 × 10−6
GUCY2C	−1.61	1.27 × 10−11	−1.36	0.010

TNBS colitis	Day 3		Day 7		Day 12
	FC	P	FC	p	FC	p
Guca2a	−3.47	0.0003	−2.40	0.0006	−1.79	0.0009
Guca2b	−1.05	0.82	2.22	0.0032	1.78	0.034
Gucy2c	−2.88	0.0002	−2.36	0.0008	−2.02	0.0024
Log2 gene expression in Healthy, un-inflamed IBD (IBD-U) and IBD Left colon and IBD Right colon

Gene	Healthy (n = 20)	IBD-U (n = 61a)		IBD Left colon (n = 33)			IBD Right colon (n = 11)			pb, f
	Log2 expression (SD)	Log2 expression (SD)	pb, c	Log2 expression (SD)	FC vs. Healthy	pb, d	Log2 expression (SD)	FC vs. Healthy	pb, e
GUCA2A	13.42 (0.21)	13.32 (0.29)	>0.99	11.29 (1.37)	−4.08	<0.0001	11.11 (1.78)	−4.63	<0.0001	>0.99
GUCA2B	10.85 (0.33)	10.90 (0.56)	>0.99	8.30 (1.21)	−6.06	<0.0001	8.30 (1.44)	−6.06	0.0003	>0.99
GUCY2C	9.92 (0.20)	9.92 (0.25)	>0.99	9.26 (0.42)	−1.59	<0.0001	9.34 (0.38)	−1.51	0.0019	>0.99

Abbreviations: CD = Crohn’s disease; FC = Fold change; IBD = Inflammatory bowel disease; TNBS = 2,4,6-Trinitrobenzene sulphonic acid; UC = Ulcerative colitis.

^aDenotes the number of samples from both IBD patients in remission without inflammatory changes, as well as samples from endoscopically and histologically un-inflamed hepatic flexure of IBD patients with inflammatory changes elsewhere in the colon.

^bData analyzed with the Kruskal–Wallis test and Dunn’s multiple comparisons test.

^cComparison between Healthy and IBD-U.

^dComparison between IBD Left colon and Healthy.

^eComparison between IBD Right colon and Healthy.

^fComparison between IBD Left colon and IBD Right colon.