Table III.

Gene expression FC and p-Values for transcription factors, cGMP mediators and transporters in IBD and TNBS colitis.

Gene/protein	UC vs. Healthy		CD vs. Healthy		TNBS colitis vs. Healthy rat colon
	FC	p	FC	p	FC	p
Transcription factors
HNF4A/Hnf4a	−1.24	1.37 × 10−7	−1.23	0.003	1.23	0.05
CDX2/Cdx2	−1.92	4.55 × 10−17	−1.37	0.01	−1.91	0.004
HNF1A/Hnf1a	−1.08	0.04	−1.10	0.004	−2.24	0
cGMP downstream mediators
PRKG2/Prkg2	−2.14	1.2 × 10−15	−2.19	2.7 × 10−7	−30.87	0.001
CNGA1/Cnga1	−1.93	2.5 × 10−8	−1.80	0.004	No data	No data
CNGA2/Cnga2	1.004	0.92	1.04	0.50	No data	No data
PDE3A/Pde3a	−1.17	0.001	−1.13	0.21	−1.08	0.21
PDE3B/Pde3b	−1.05	0.30	1.07	0.56	−1.08	0.39
PDE5/Pde5	−1.34	0.007	−1.15	0.59	1.33	0.05
CFTR/Cftr	−1.84	2.2 x 10−10	−1.59	0.004	−2.64	0.0002
SLC9A3/Slc9a3	−1.21	2.6 x 10−5	−1.17	0.06	−4.59	0.002
cGMP transporters
MRP4/Mrp4	1.06	0.94	1.02	0.52	No data	No data
MRP5/Mrp5	−1.23	0.12	−1.25	0.007	−1.15	0.29

Abbreviations: CD = Crohn’s disease; CFTR = Cystic fibrosis transmembrane conductance regulator; cGMP = Cyclic guanosine-3′,5′-monophosphate; FC = Fold change; IBD = Inflammatory bowel disease; MRP = Multidrug resistance protein; PDE = Phosphodiesterase; TNBS = 2,4,6-Trinitrobenzene sulphonic acid; UC = Ulcerative colitis.