Table III.
Gene/protein | UC vs. Healthy |
CD vs. Healthy |
TNBS colitis vs. Healthy rat colon |
|||
---|---|---|---|---|---|---|
FC | p | FC | p | FC | p | |
Transcription factors | ||||||
HNF4A/Hnf4a | −1.24 | 1.37 × 10−7 | −1.23 | 0.003 | 1.23 | 0.05 |
CDX2/Cdx2 | −1.92 | 4.55 × 10−17 | −1.37 | 0.01 | −1.91 | 0.004 |
HNF1A/Hnf1a | −1.08 | 0.04 | −1.10 | 0.004 | −2.24 | 0 |
cGMP downstream mediators | ||||||
PRKG2/Prkg2 | −2.14 | 1.2 × 10−15 | −2.19 | 2.7 × 10−7 | −30.87 | 0.001 |
CNGA1/Cnga1 | −1.93 | 2.5 × 10−8 | −1.80 | 0.004 | No data | No data |
CNGA2/Cnga2 | 1.004 | 0.92 | 1.04 | 0.50 | No data | No data |
PDE3A/Pde3a | −1.17 | 0.001 | −1.13 | 0.21 | −1.08 | 0.21 |
PDE3B/Pde3b | −1.05 | 0.30 | 1.07 | 0.56 | −1.08 | 0.39 |
PDE5/Pde5 | −1.34 | 0.007 | −1.15 | 0.59 | 1.33 | 0.05 |
CFTR/Cftr | −1.84 | 2.2 x 10−10 | −1.59 | 0.004 | −2.64 | 0.0002 |
SLC9A3/Slc9a3 | −1.21 | 2.6 x 10−5 | −1.17 | 0.06 | −4.59 | 0.002 |
cGMP transporters | ||||||
MRP4/Mrp4 | 1.06 | 0.94 | 1.02 | 0.52 | No data | No data |
MRP5/Mrp5 | −1.23 | 0.12 | −1.25 | 0.007 | −1.15 | 0.29 |
Abbreviations: CD = Crohn’s disease; CFTR = Cystic fibrosis transmembrane conductance regulator; cGMP = Cyclic guanosine-3′,5′-monophosphate; FC = Fold change; IBD = Inflammatory bowel disease; MRP = Multidrug resistance protein; PDE = Phosphodiesterase; TNBS = 2,4,6-Trinitrobenzene sulphonic acid; UC = Ulcerative colitis.