Figure 2.

Schematic representation of serum and secretory antibody responses following administration of IPV to OPV- or IPV-primed individuals. Primary immunization with OPV induces both a humoral response (serum IgG) and a mucosal response (intestinal and nasopharyngeal IgA), whereas IPV induces only a humoral response and potentially a limited mucosal response in the nasopharynx. However, following the waning of OPV-induced mucosal immunity, administration of IPV is capable of boosting both humoral and mucosal immunity in OPV-primed individuals. The same boosting of humoral immunity does not occur among individuals without prior OPV exposure.

IPV: Inactivated poliovirus vaccine; OPV: Oral poliovirus vaccine.
Informed by [16,17,22,23].