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. 2015 Jul 21;26(6):507–520. doi: 10.3109/09537104.2015.1064881

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© 2015 The Author(s). Published with license by Informa UK Ltd.

© G. Ed Rainger, Myriam Chimen, Matthew J. Harrison, Clara M. Yates, Paul Harrison, Stephen P. Watson, Marie Lordkipanidzé, and Gerard B. Nash

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Targets for therapeutic intervention in platelet–leukocyte adhesion and in the platelet-mediated recruitment of leukocytes: (A) Therapeutic agents that inhibit the adhesive interactions between platelets and leukocytes or which inhibit the activation of platelets by antagonising platelet derived positive feedback loops which amplify the platelet response to primary activating stimuli. (B) Therapeutic agents that inhibit platelet adhesion to the vessel wall by either antagonising adhesive pathways directly or by inhibiting endothelial cell activation in response to platelet borne activating stimuli. AA, Arachidonic acid; ADP, Adenosine diphosphate; α-G, Alpha granule; COX-1, Cyclooxygenase-1; DG, Dense granule; P2Y12, ADP receptor; PGG2, Prostaglandin G2; PSGL1, P-selectin glycoprotein ligand1; TP, Thromboxane A2 receptor; TxA2, Thromboxane A2; TxSy, Thromboxane synthase.