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. 2015 Nov 4;3(11):e12544. doi: 10.14814/phy2.12544

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Deletion of Jagged1 within renin cells. (A) A schematic of the breeding strategy for conditional deletion of Jagged1 in renin cells. (B) Jagged1 deletion efficiency as measured by quantitative PCR. There was >50% reduction in Jagged1 expression levels at each time point (*P < 0.05; **P < 0.01, n = 4, 5, 2, and 4 for control and 2, 5, 2, and 4, for mutant kidneys at 1 week, 2 weeks, 4 weeks, and 1 year, respectively). (C) Immunostaining for Jagged1 (brown staining) in 1-week-old control and mutant kidney sections. Scale bar: 100 μm. G = glomeruli, A = artery, AA = afferent arteriole, CD = collecting duct.