Table 3.
Plasmatic and urinary osmolality and free water clearance before and after dilution/oral water load test in patients affected by SIADH or with a normal response (defined a posteriori)
| Baseline | Post dilution test (H3) | Diagnosis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| P Na+ | P Osm | U Osm | Free H2O Cl. mL/min | PNa+ | P Osm | U Osm | Free H2O Cl. mL/min | ||
| Group 3: Normal response to dilution | |||||||||
| Patient 9 | 137 | 296 | 794 | −1.07 | 133 | 285 | 201 | 1.34 | Past history of SIADH |
| Patient 10 | 139 | 290 | 885 | −2.77 | 138 | 286 | 132 | 3.97 | Past history of SIADH |
| Patient 11 | 140 | 291 | 313 | −0.15 | 139 | 285 | 104 | 4.03 | Past history of water intoxication |
| Patient 12 | 137 | 286 | 915 | −1.4 | 135 | 284 | 75 | 6.5 | Past history of SIADH |
| Median | 138 | 290.5 | 839.5 | −1.23 | 136.5 | 285 | 118 | 4 | |
| Group 4:SIADH | |||||||||
| Patient 13 | 132 | 277 | 460 | 0.59 | 127 | 268 | 591 | 0.28 | SIADH |
| Patient 14 | 130 | 282 | 403 | −0.76 | 130 | 277 | 613 | −0.47 | SIADH |
| Patient 15 | 132 | 275 | 322 | −0.5 | 132 | 274 | 267 | 0.07 | SIADH |
| Patient 16 | 139 | 306 | 580 | −0.73 | 133 | 290 | 268 | 0.14 | SIADH (partial response) |
| Patient 17 | 135 | 286 | 556 | −1.75 | 133 | 274 | 308 | −0.42 | SIADH (partial response) |
| Patient 18 | 135 | 291 | 369 | −0.6 | 130 | 277 | 281 | −0.03 | SIADH (partial response) |
| Median | 133.5 | 284 | 431.5 | −0.67 | 131 | 275.5 | 294.5 | 0.02 | |
| D | 0.05 | 0.33 | 0.26 | 0.35 | 0.02 | 0.11 | 0.01 | 0.01 | |
P Na+, sodium serum level; P Osm, plasmatic osmolality; U Osm, urinary osmolality; Free H2O Cl, free water clearance; SIADH, syndrome of inappropriate antidiuretic hormone secretion.