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. 2015 Nov 4;3(11):e12584. doi: 10.14814/phy2.12584

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Experimental protocol. Thirty-four female Sprague Dawley rats were implanted with an intraperitoneal slow release pellet continuously delivering either a low (53 μg·day⁻¹) or a high (207 μg·day⁻¹) dose of lipopolysaccharide (LPS), or containing only pellet matrix. One week after the surgery, half of the rats were switched onto a high-fat diet (HFD), while the other half were given a control (CON) diet. Body mass and food intake was measured for 6.5 weeks after diet change. Oral glucose tolerance test (OGTT) was performed 6–7 weeks after pellet implantation. Rats were euthanized 8 weeks after pellet implantation.