Table 3.
Appetite-regulating gene expression in hypothalamus
| Gene | Control diet | High-fat diet | ||||
|---|---|---|---|---|---|---|
| Vehicle | LPSlow dose | LPShigh dose | Vehicle | LPSlow dose | LPShigh dose | |
| Orexin* | 100.0 ± 18.16 | 171.6 ± 25.66 | 72.27 ± 20.59 | 93.03 ± 23.93 | 154.8 ± 26.05 | 84.63 ± 16.09 |
| AgRP | 100.0 ± 20.44 | 85.51 ± 10.52 | 91.54 ± 20.93 | 76.02 ± 6.87 | 97.97 ± 16.67 | 95.16 ± 15.76 |
| NPY | 100.0 ± 19.57 | 94.14 ± 9.23 | 63.25 ± 1.60 | 74.15 ± 6.91 | 84.38 ± 5.11 | 85.12 ± 14.97 |
| NPYR1 | 100.0 ± 8.21 | 81.03 ± 3.80 | 93.26 ± 10.04 | 96.04 ± 6.11 | 94.76 ± 4.84 | 104.8 ± 6.47 |
| NPYR2 | 100.0 ± 19.47 | 103.8 ± 7.89 | 101.7 ± 6.64 | 118.2 ± 3.36 | 116.7 ± 5.09 | 104.8 ± 5.21 |
| POMC | 100.0 ± 15.16 | 86.38 ± 7.10 | 73.41 ± 8.43 | 77.25 ± 13.37 | 84.07 ± 7.49 | 78.70 ± 6.68 |
| Pmch | 100.0 ± 19.45 | 134.8 ± 9.48 | 141.7 ± 6.79 | 134.3 ± 14.94 | 131.8 ± 10.73 | 113.6 ± 21.77 |
| LR | 100.0 ± 10.20 | 112.7 ± 18.96 | 78.21 ± 8.71 | 83.36 ± 16.36 | 81.00 ± 8.81 | 96.05 ± 19.66 |
| FTO | 100.0 ± 3.47 | 92.53 ± 5.76 | 89.68 ± 8.82 | 88.15 ± 4.24 | 96.82 ± 2.88 | 92.05 ± 7.43 |
| Cart | 100.0 ± 6.72 | 93.25 ± 6.40 | 91.99 ± 9.03 | 99.50 ± 11.28 | 97.41 ± 5.07 | 111.1 ± 13.84 |
Data are presented as mean percentage of CON-vehicle ± SEM (n = 4–5 per group).
*
Significant effect of LPS (two-way ANOVA, P < 0.05).