Table 3.

Common pathway model results: phenotypic, genetic and non-shared environmental correlations between the latent factors and time-specific influences at 15, 17 and 20 years

	Depression	Panic	Generalized anxiety	Separation anxiety
Latent factors
Panic
rphl	0.72 (0.67 to 0.76)
rAl	0.74 (0.66 to 0.83)
rEl	0.67 (0.46 to 0.85)
Generalized anxiety
rphl	0.74 (0.69 to 0.79)	0.83 (0.79 to 0.87)
rAl	0.81 (0.73 to 0.88)	0.86 (0.79 to 0.94)
rEl	0.60 (0.41 to 0.76)	0.76 (0.61 to 0.89)
Separation anxiety
rphl	0.58 (0.51 to 0.65)	0.76 (0.70 to 0.82)	0.80 (0.75 to 0.85)
rAl	0.60 (0.48 to 0.71)	0.78 (0.67 to 0.89)	0.86 (0.76 to 0.96)
rEl	0.55 (0.29 to 0.80)	0.73 (0.51 to 0.95)	0.70 (0.50 to 0.89)
Social anxiety
rphl	0.63 (0.58 to 0.68)	0.62 (0.56 to 0.67)	0.75 (0.71 to 0.79)	0.65 (0.59 to 0.70)
rAl	0.67 (0.59 to 0.76)	0.68 (0.57 to 0.78)	0.77 (0.69 to 0.85)	0.75 (0.64 to 0.87)
rEl	0.56 (0.37 to 0.72)	0.52 (0.34 to 0.67)	0.71 (0.58 to 0.83)	0.46 (0.24 to 0.65)
Time-specific influences at 15
Panic
rphs	0.43 (0.38 to 0.48)
rAs	0.80 (0.59 to 0.99)
rEs	0.28 (0.19 to 0.38)
Generalized anxiety
rphs	0.44 (0.39 to 0.48)	0.49 (0.44 to 0.52)
rAs	0.57 (0.37 to 0.74)	0.56 (0.32 to 0.73)
rEs	0.38 (0.28 to 0.46)	0.46 (0.38 to 0.53)
Separation anxiety
rphs	0.34 (0.29 to 0.39)	0.40 (0.36 to 0.45)	0.43 (0.38 to 0.48)
rAs	0.40 (0.15 to 0.59)	0.64 (0.41 to 0.86)	0.58 (0.38 to 0.76)
rEs	0.31 (0.22 to 0.41)	0.31 (0.22 to 0.40)	0.36 (0.27 to 0.44)
Social anxiety
rphs	0.36 (0.31 to 0.41)	0.37 (0.32 to 0.42)	0.48 (0.44 to 0.52)	0.46 (0.42 to 0.51)
rAs	0.61 (0.38 to 0.81)	0.64 (0.39 to 0.88)	0.81 (0.62 to 0.99)	0.66 (0.44 to 0.86)
rEs	0.26 (0.16 to 0.36)	0.28 (0.18 to 0.37)	0.35 (0.25 to 0.43)	0.39 (0.29 to 0.47)
Time-specific influences at 17
Panic
rphs	0.19 (0.09 to 0.28)
rAs	0.41 (−1.00 to 1.00)
rEs	0.15 (0.00 to 0.30)
Generalized anxiety
rphs	0.27 (0.16 to 0.37)	0.38 (0.29 to 0.47)
rAs	−0.13 (1.00 to 1.00)	0.85 (−1.00 to 1.00)
rEs	0.29 (0.13 to 0.41)	0.38 (0.23 to 0.52)
Separation anxiety
rphs	−0.12 (−0.20 to 0.04)	0.02 (−0.06 to 0.09)	0.11 (0.02 to 0.20)
rAs	−0.33 (−1.00 to 1.00)	−0.16 (−0.60 to 0.20)	0.04 (−1.00 to 1.00)
rEs	−0.08 (−0.22 to 0.05)	0.09 (−0.06 to 0.23)	0.13 (−0.02 to 0.27)
Social anxiety
rphs	0.12 (0.01 to 0.22)	0.05 (−0.06 to 0.14)	0.16 (0.03 to 0.27)	0.03 (−0.06 to 0.11)
rAs	−0.45 (−1.00 to 1.00)	−0.94 (−1.00 to −0.12)	−0.76 (−1.00 to 1.00)	0.48 (−0.27 to 0.99)
rEs	0.17 (0.03 to 0.31)	0.20 (0.05 to 0.33)	0.20 (0.06 to 0.36)	−0.05 (−0.19 to 0.09)
Time-specific influences at 20
Panic
rphs	0.36 (0.30 to 0.42)
rAs	0.72 (0.05 to 1.00)
rEs	0.30 (0.19 to 0.40)
Generalized anxiety
rphs	0.42 (0.37 to 0.47)	0.44 (0.39 to 0.49)
rAs	0.45 (−0.15 to 0.79)	0.48 (−0.07 to 0.98)
rEs	0.42 (0.31 to 0.51)	0.44 (0.35 to 0.53)
Separation anxiety
rphs	0.38 (0.32 to 0.44)	0.44 (0.38 to 0.50)	0.47 (0.41 to 0.52)
rAs	0.66 (0.15 to 0.98)	0.61 (−0.58 to 1.00)	0.63 (−0.01 to 0.95)
rEs	0.32 (0.21 to 0.42)	0.42 (0.32 to 0.52)	0.43 (0.33 to 0.53)
Social anxiety
rphs	0.45 (0.40 to 0.50)	0.47 (0.41 to 0.52)	0.56 (0.51 to 0.61)	0.43 (0.37 to 0.48)
rAs	0.74 (0.31 to 0.99)	0.70 (−0.25 to 1.00)	0.69 (0.13 to 0.94)	0.33 (−0.43 to 0.79)
rEs	0.38 (0.28 to 0.48)	0.43 (0.34 to 0.53)	0.53 (0.45 to 0.62)	0.45 (0.34 to 0.55)

r_phl, Phenotypic correlations between the latent factors; r_Al, genetic correlations between the latent factors; r_El, non-shared environmental correlations between the latent factors; r_phs, phenotypic correlations between the time-specific influences; r_As, genetic correlations between the time-specific influences; r_Es, non-shared environmental correlations between the time-specific influences.

95% confidence intervals (CIs) are presented in parentheses. CIs not inclusive of zeros indicate significant correlations. Non-overlapping CIs mean significant difference between the values.

AE models are presented, as C influences were not significant and were dropped from the multivariate models without a significant deterioration of the fit (Supplementary Table S2). The AIC values suggest that dropping C lead to improvement of the model fit at these three waves. Full ACE results are presented in Supplementary Tables S3–S5 for completeness.