Table 1.
Baseline characteristics, according to health status prior to TAVR
| KCCQ <25 (N=2194) |
KCCQ 25–49 (N=2936) |
KCCQ 50–74 (N=1886) |
KCCQ 75–100 (N=753) |
P for trend |
|
|---|---|---|---|---|---|
| Age, yr | 84 (78,88) | 84 (79,88) | 85 (80,89) | 85 (80,89) | <0.001 |
| Male sex | 41.7% | 48.1% | 48.7% | 53.4% | <0.001 |
| Body surface area, m2 | 1.8 (1.7,2.0) | 1.8 (1.6,2.0) | 1.8 (1.6,1.9) | 1.8 (1.6,1.9) | <0.001 |
| Prior PCI | 34.8% | 36.7% | 35.3% | 32.9% | 0.516 |
| Prior CABG | 28.3% | 32.6% | 32.1% | 31.4% | 0.031 |
| Peripheral arterial disease | 31.4% | 33.7% | 33.7% | 30.7% | 0.693 |
| Hypertension | 91.2% | 89.3% | 90.3% | 89.3% | 0.231 |
| Oxygen-dep lung disease | 22.0% | 13.0% | 7.3% | 4.5% | <0.001 |
| Diabetes mellitus | 39.5% | 34.1% | 30.7% | 31.0% | <0.001 |
| On insulin | 15.9% | 11.8% | 9.0% | 8.4% | <0.001 |
| Prior stroke or TIA | 19.5% | 18.8% | 18.6% | 17.6% | 0.239 |
| Hemoglobin, g/dL | 11.2 (10.1,12.5) | 11.8 (10.6,12.9) | 11.9 (10.8,13.0) | 12.1 (10.9,13.1) | <0.001 |
| Creatinine, mg/dL | 1.1 (0.9,1.5) | 1.1 (0.9,1.4) | 1.1 (0.8,1.4) | 1.0 (0.8,1.4) | <0.001 |
| Current dialysis | 4.7% | 3.6% | 2.0% | 2.1% | <0.001 |
| 5-Meter Walk Test attempted | 58.8% | 69.3% | 72.9% | 73.3% | <0.001 |
| STS Mortality Score | 8.2 (5.4,12.3) | 6.9 (4.8,10.5) | 6.5 (4.4,9.6) | 5.9 (4.0,8.7) | <0.001 |
| Aortic valve area, cm2 | 0.6 (0.5,0.8) | 0.7 (0.5,0.8) | 0.7 (0.5,0.8) | 0.7 (0.5,0.8) | 0.019 |
| Mean aortic gradient, mmHg | 43.0 (35.0,51.0) | 43.0 (36.0,52.0) | 44.0 (36.0,53.0) | 45.0 (38.0,55.0) | <0.001 |
| Aortic regurgitation (mod/sev) | 21.0% | 19.7% | 18.6% | 19.4% | 0.127 |
| Mitral regurgitation (mod/sev) | 40.7% | 34.4% | 36.2% | 30.5% | <0.001 |
Data are presented as median (Q1–Q3) or %
TAVR, transcatheter aortic valve replacement; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft surgery; TIA, transient ischemic attack; STS, Society of Thoracic Surgeons