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. 2015 Dec 9;5:17956. doi: 10.1038/srep17956

Figure 4. EP1 antagonist administration reduces blood-brain barrier permeability and hemorrhagic transformation.

Figure 4

Immunoglobulin G and hemoglobin levels are extremely low in the healthy brain, therefore were used as indicators of the degree of blood-brain barrier permeability and hemorrhagic transformation, respectively. (A) IgG concentrations in the cortex were divided by plasma concentrations to yield a corrected measure of blood-brain barrier permeability. Corrected IgG levels are reduced in the ischemic cortex of SC-51089-treated rats compared to the vehicle (P < 0.05). (B) Cortical IgG concentration were divided by the plasma concentration and infarct volume of the section used for molecular analyses gives an approximate measure of IgG per cubic volume of infarcted tissue. IgG/unit of infarcted tissue is reduced in SC-51089-treated animals compared to the vehicle (P < 0.01, unpaired two-tailed t-test). (C) Average hemoglobin levels were significantly reduced in SC-51089-treated rats (1.90 ± 0.39 ng/μg) compared to the vehicle-treated group (3.20 ± 0.36 ng/μg) (P = 0.0243, two-tailed unpaired t-test). Vehicle N = 10, SC-51089 N = 11. CXi = Cortex ipsilateral to stroke; CXc = Cortex contralateral to stroke.