Table 2. Sequence variants in the EnhII/BCP/PC regions of HBeAg-positive CHB patients.
| Total | Genotype C | Genotype B | |||
|---|---|---|---|---|---|
| Region | Variant | (n = 58) (%) | (n = 40) (%) | (n = 18) (%) | Pvalue |
| EnhII | G1719T | 28 (48.3) | 24 (60.0) | 4 (22.2) | 0.0107 |
| (1685–1773) | A1726C | 18 (31.0) | 3 (7.5) | 15 (83.3) | <.0001 |
| A1727Vc (T1727Vb) | 30 (51.7) | 24 (60.0) | 6 (33.3) | ||
| BCP | G1746A | 56 (96.6) | 39 (97.5) | 17 (94.4) | 0.5281 |
| (1742–1849) | A1752G/T | 17 (29.3) | 3 (7.5) | 14 (77.8) | <.0001 |
| T1753V | 22 (37.9) | 20 (50.0) | 2 (11.1) | 0.0075 | |
| A1762T | 35 (60.3) | 28 (70.0) | 7 (38.9) | 0.0413 | |
| G1764A | 35 (60.3) | 28 (70.0) | 7 (38.9) | 0.0413 | |
| PC | C1817G/A | 18 (31.0) | 11 (27.5) | 7 (38.9) | 0.5404 |
| (1814–1900) | T1825C/A | 58 (100.0) | 40 (100.0) | 18 (100.0) | |
| A1846T | 19 (32.8) | 10 (25.0) | 9 (50.0) | 0.0757 | |
| G1896A | 29 (50.0) | 18 (45.0) | 11 (61.1) | 0.3950 |
For all nucleotide positions in EnhII/BCP/PC regions, the most prevalent nucleotide type among HBV genotype B or genotype C infection patients in china were used as reference nucleotide. EnhII, enhancer II; BCP, basal core promoter; PC, precore; cGenotype C; bGenotype B; A, adenine; G, guanine; C, cytosine; T, thymine. Data presented as no. (%). P, Fisher’s exact test.