Table 2.
GSEA on FEM modules revealed strong enrichment of two FEMs with seed genes CAV1 and FSTL1, respectively
| FEM | Size | Enriched pathway | Overlap | Overlapping genes |
|---|---|---|---|---|
| CAV1 | 58 | WNT signalling | 23 | DKK1 WNT3A FZD9 WNT2 WNT7A IGFBP4 |
| FZD8 FZD1 LRP6 FZD2 LRP5 FZD6 RSPO1 | ||||
| WNT5A RYK FZD5 ATP6AP2 WNT3 WIF1 | ||||
| WNT1 WNT7B FZD10 SFRP1 | ||||
| FSTL1 | 56 | TGF-beta signalling | 18 | NOG GDF5 CHRD TGFB2 TGFB1 FST TGFB3 |
| BMPR2 GDF6 BMPR1A BMPR1B ACVRL1 | ||||
| ACVR2A BMP4 BMP2 BMP7 BMP6 INHBE |
Columns label the FEM module size, the main enriched pathway, the number of overlapping genes between FEM and pathway and the overlapping genes