Skip to main content
. Author manuscript; available in PMC: 2016 Nov 13.
Published in final edited form as: Annu Rev Cell Dev Biol. 2015 Nov 13;31:623–646. doi: 10.1146/annurev-cellbio-100814-125315

Figure 1.

Figure 1

Schematic depiction of Wnt-Frizzled/planar cell polarity (Fz/PCP) core component interactions across a two-cell border in Drosophila. Fz and Van Gogh (Vang) act in the interpretation of both long-range signal(s)—likely Wg/dWnt4 gradients—and short-range/local cell-cell transmembrane interactions. The latter is also mediated by the homophilic interactions of Flamingo (Fmi) and Furrowed (Fw), which are thought to physically interact with Fz and Vang and just Fz, respectively. The cytoplasmic components Dishevelled (Dsh), Diego (Dgo), and Prickle (Pk) are essential for negative intracellular feedback loops within individual cells, as they antagonize each other, and for activating intracellular pathways; for example, Dsh promotes actin polymerization by activating/localizing Rho-family GTPases and downstream effectors such as dROK (Rho-associated kinase). Inturned (In) and Fuzzy (Fy) serve to recruit Multiple wing hairs (Mwh), which is thought to inhibit actin polymerization. For more details and for Fz-Dsh downstream intracellular signaling pathways, readers are referred to Adler (2002), Mlodzik (2002), Strutt (2003), and Veeman et al. (2003).