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. Author manuscript; available in PMC: 2015 Dec 9.
Published in final edited form as: J Med Chem. 2012 Jul 11;55(14):6639–6643. doi: 10.1021/jm300677j

Figure 1. Subfamilies of the human 2-oxoglutarate (‘JmjC’) histone demethylases, showing their domain architecture.

Figure 1

Not all proposed family members are shown. Each demethylation reaction is coupled to 2OG decarboxylation and formaldehyde production. KIAA1718 has recently been assigned as KDM7A, however its JmjC domain shows high sequence and structural similarity with the KDM2 subfamily members.