Table 2.

Global physicochemical parameters calculated for compounds 1a-i.

Derivative	CLog P	R	P	V	SA
					Approx	Grid
1a	4.13	74.01	29.04	728.65	350.18	450.79
1b	4.27	74.22	28.94	732.23	356.62	452.41
1c	4.65	78.81	30.96	768.53	376.46	474.03
1d	4.65	78.81	30.96	781.96	392.35	486.85
1e	4.65	78.81	30.96	772.99	385.48	473.83
1f	4.92	81.63	31.66	792.01	394.56	485.00
1g	4.60	79.05	30.87	782.24	382.59	485.04
1h	4.60	79.05	30.87	781.82	393.27	478.63
1i	3.88	80.47	31.51	806.46	408.80	495.65