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. Author manuscript; available in PMC: 2015 Dec 9.
Published in final edited form as: JAMA Neurol. 2015 Jul;72(7):781–788. doi: 10.1001/jamaneurol.2015.0582

Table 2.

Association Results for Coding Region Variants and Risk of Ischemic Stroke With a Meta-analysis P<5×10−6 Displayed

OR
 P Value
 No. of SNVs in SKAT SKAT Gene-Level P Value
Gene Location Gene Size, kb Associated SNV MAF Discovery Replication Meta-analysis Discovery Replication Meta-analysis Discovery Replication Meta-analysis
PDE4DIP 1q21.1 240.030 rs1778155 0.316 2.147 NA 2.147 2.63 × 10−8 NA 2.63 × 10−8 42 .97 .24 .45
ACOT4 14q24.3 4.791 rs35724886 0.017 2.044 NA 2.044 1.24 × 10−7 NA 1.24 × 10−7 1 1.36 × 10−7 NA 1.36 × 10−7
PRIM2 6p11.2 333.773 rs5001076 0.379 2.105 NA 2.105 2.96 × 10−6 NA 2.96 × 10−6 4 7.2 × 10−5 NA 7.2 × 10−5

Abbreviations: kb, kilobase; MAF, minor allele frequency; OR, odds ratio; SNV, single-nucleotide variant; SKAT, sequence kernel association test.