Table 3.
Association Results for Coding Region Variants and Risk of Small-Vessel Ischemic Stroke With Meta-analysis P<5×10−4 Displayed
| Test Results |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR |
P Value |
|||||||||
| Gene | Location | Gene Size, kb | SNV | MAF | ESP Sequence | Exome-Chip | Meta-analysis | ESP Sequence | Exome-Chip | Meta-analysis |
| Single-Variant Test Used | ||||||||||
|
| ||||||||||
| PDE4DIP | 1q21.1 | 240.030 | Best, rs1778155 | 0.308 | 2.029 | NA | 2.029 | 7.96 × 10−6 | NA | 7.96 × 10−6 |
|
| ||||||||||
| ACOT4 | 14q24.3 | 4.791 | Best, rs35724886 | 0.018 | 1.952 | NA | 1.952 | 2.43 × 10−5 | NA | 2.43 × 10−5 |
|
| ||||||||||
| Gene-Based Test Used (SKAT) | ||||||||||
|
| ||||||||||
| CEP164 | 11q23.3 | 98.712 | n = 24 | Cumulative, 0.010 | NA | NA | NA | .15 | 4.9 × 10−6 | 7.93 × 10−6 |
Abbreviations: kb, kilobase; MAF minor allele frequency; NA, not applicable; OR, odds ratio; SKAT, sequence kernel association test; SNV, single-nucleotide variant.