Table 2.
Original data for BTXA in treatment of frey’s syndrome
| First author | Year | No. of participants | CB (U/mL) | V (mL) | ID (mm) | Total dose per patient (U) | Mean duration of effect (M) | Note |
|---|---|---|---|---|---|---|---|---|
| M. Naumann | 1997 | 45 | 20 | 0.05–0.1 | 15 | 21.1 (5–72) | >6 | |
| A. Bjerkhoel | 1997 | 14 | 25 | 0.1 | 10 | 37.7 (17–62.5) | >6.6 | 2 |
| R. Laskawi | 1998 | 19 | 25 | 0.1 | 20 | 31.3 (2.5–100) | 17.3 | 2 |
| O. Laccourreye | 1999 | 33 | 25 | 0.1 | 10 | 86 (25–175) | 10 | 2 |
| J. J. von Lindern | 2000 | 7 | 20 | 0.1 | 20 | 297 (250–380) | >20 | |
| P. Dulguerov | 2000 | 15 | 50 | 0.1 | 10 | 15–75 | >3 | |
| A. Arad-Cohen | 2000 | 7 | 25 | 0.1 | 10 | 22.2 (12.5–30) | 12.1 | 2 |
| S. Rodopoulou | 2001 | 9 | 25 | 0.1 | 15 | 22.66 (12.5–34) | >14 | |
| R. Laskawi | 2001 | 43 | 25 | 0.1 | 20 | NA | NA | 2 |
| V. Tugnoli | 2002 | 17 | 20 | 0.1 | 15 | 25–55 | >7 (7–18) | 2 |
| O. Guntinas-Lichius | 2002 | 20 | 251 | 0.1 | 10 | About 37 | 8.3 | 2 |
| O. Guntinas-Lichius | 2002 | 20 | 501 | 0.1 | 10 | About 62 | 18.5 | 2 |
| A. J. F Beeren | 2002 | 13 | 75 | 0.1 | 20 | 100 (67.5–150) | 11 | 2 |
| A. Eckardt | 2003 | 33 | 22.5 | 0.1 | 15 | 16–80 | >12 | 2 |
| D. E. Kyrmizakis | 2004 | 11 | 25 | 0.1 | 20 | 22.5 (15–52.5) | 10 | 2 |
| Chen-Chi Wang | 2005 | 10 | 25 | 0.1 | 10 | 46.4 (15–137.5) | 9.3 (2–28) | 2 |
| M. Pornprasit | 2007 | 9 | 20 | 0.1 | 10 | 10.6 (2–32) | 9.2 | |
| Kuauhyama Luna Ortiz | 2007 | 23 | 25 | NA | NA | 0.71–42 | About 6 | |
| D. M. Hartl | 2008 | 17 | 25 | 0.1 | 10 | 96 (55–125) | 18 | |
| P. M. Diaz | 2008 | 10 | 16 | 0.1 | 10 | 38 (17–84) | 15 | 2 |
| P. Capaccio | 2008 | 6 | NA | NA | 10 | 41 (25–100) | >4 | 2 |
| R. de Bree | 2009 | 22 | 18.751 | 0.1 | 20 | 101 (30–300) | 5.2 | 2 |
| A. Steffen | 2012 | 8 | 501 | 0.05 | 10 | Unavailable | 7.8 |
CB, concentration of Botox; V, volume per injection site; ID, interjection distance; MDU, maximal dose used; FS, Frey’s syndrome; NA, not available.
1
2.5 U botox = 10 U disport.
2
Reinjection for recurrent patients without any complications.