Table 1.
Previous studies reporting the association between preoperative serum tumor markers and outcomes in patients with esophageal cancer
| Reference | Year of publication | No. patients (No. ESCC/No. EAC) | CEA cut-off value (ng/mL) | CEA-positive ratio (%) | CA19-9 cut-off value (U/mL) | CA19-9 positive ratio (%) | SCC antigen cut-off value (ng/mL) | SCC antigen positive ratio (%) | P-value for overall survival | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||||||||||
| CEA | CA19-9 | SCC | CEA | CA19-9 | SCC | |||||||||
| Clark et al. 13 | 1995 | 100 (20/80) | 5.0 | 19.0 | — | — | — | — | 0.690 | — | — | — | — | — |
| Mroczko et al. 14 | 2008 | 89 (63/26) | 4.0 | 17.0 | — | — | 2.0 | 64.0 | 0.488 | — | 0.468 | — | — | — |
| Lukaszewicz-Zajac et al. 15 | 2012 | 53 (30/23) | 4.0 | 30.0 | — | — | 2.0 | 24.0 | 0.728 | — | 0.127 | — | — | — |
| Scarpa et al. 16 | 2014 | 243 (82/161) | 5.0 | 14.7 | 37.0 | 12.3 | — | — | — | — | — | — | — | — |
“—” means that there is no examination. ESCC, esophageal squamous cell carcinoma; EAC, esophageal adenocarcinoma; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; SCC, squamous cell carcinoma.