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. Author manuscript; available in PMC: 2016 Dec 2.
Published in final edited form as: Neuron. 2015 Dec 2;88(5):985–998. doi: 10.1016/j.neuron.2015.11.003

Figure 3. Pairing of Odor and DAN Activation Induces Synaptic LTD.

Figure 3

(A) Expression of CsChrimson and GFP was driven by MB320C and R12G04-LexA, respectively. Whole-cell voltage-clamp recordings were made from MBON-γ1pedc. Action potentials were completely suppressed by QX-314 in the pipette solution.

(B) Representative voltage-clamp data from a single cell, showing odor-evoked EPSCs before (Pre) and after (Post) pairing. Gray bar, 1-s odor presentation. Overlaid traces (bottom) show mean EPSCs pre- and post-pairing in this cell (n = 5-7 trials). Scale bar, 200 pA.

(C) Mean EPSCs (± SEM, shaded area; n = 5 cells).

(D) Mean charge transfer of EPSC (± SEM). Gray lines indicate data from individual flies. Excitatory synaptic input decreased for CS+ (p < 0.005, Tukey’s post hoc test following repeated measures two-way ANOVA) but not for CS− (p > 0.1).