Table 1. Solute plasma levels, clearance rates, and excretion rates for study participants.
| Plasma Levels | Clearances* | Excretion/Removal** | ||||||
|---|---|---|---|---|---|---|---|---|
| Solute | UN*** | Creatinine | TMAO | Urea | Creatinine | TMAO | Urea | TMAO |
| mg/dl | mg/dl | μM | ml/min | g/day | μmoles/day | |||
| Normals (n = 6) | 15±3 | .85±.18 | 2±1 | 55±14 | 119°±21 | 219° ‡ ±78 | 24±6 | 533 ±272 |
| ESRD (n = 7) | 45 † ±11 | 10.79 † ±3.09 | 77 † ±26 | 258±58 | 174° † ±52 | 165°±72 | 12 † ±6 | 606 ±220 |
Means ± standard deviations
† p < .05 Normal vs. ESRD
° p< .05 Creatinine and TMAO clearances vs urea clearance within each group
‡ p< .05 TMAO vs creatinine clearance
*Clearances are urinary clearances for normal and dialytic clearances for ESRD.
**Excretion is 24 hour urinary excretion for normal. For ESRD, removal is the amount removed in dialysate and ultrafiltrate divided by 2 to adjust for the 2 day interdialytic interval.
*** UN is urea nitrogen.