Fig 4. NF-κB binds to the DEFB131 gene promoter.

(A) Five potential NF-κB/p65 binding sequences are located in the human DEFB131 promoter region. The differences in the site sequences from the consensus NF-κB binding sequences (CBS) are indicated by asterisks. CBS, GGGRNNYYCC or HGGARNYYCC; R, purine; Y, pyrimidine; H, A, C, or T. (B) Chromatin immunoprecipitation assays with antibody directed against NF-κB were performed on RWPE-1 cells treated with LTA. Different letters indicate significant differences between groups at P < 0.05 or P < 0.005.